Publication

• Saito T *, Kurazumi H, Suzuki R, Matsunaga K, Tsubone S, Lv B, Kobayashi S, Nagase T, Mizoguchi T, Samura M, Suehiro K, Harada T, Morikage N, Mikamo A, Hamano K.
  Perivascular Adipose Tissue is a Major Source of Nitric Oxide in Saphenous Vein Grafts Harvested via the No-touch Technique.
  J Am Heart Assoc. 11, e020637. 2022
• Nah J, Shirakabe A, Mukai R, Zhai P, Sung EA, Ivessa A, Mizushima W, Nakada Y, Saito T, Hu C, Jung YK, Sadoshima J.
  Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.
  Cardiovasc Res. 118, 2638-2651. 2022 (IF: 13.3)
• Matsuno Y, Yanagihara M, Ueno K, Saito T, Kurazumi H, Suzuki R, Katsura S, Oga A, Hamano K.
  Dry preserved multilayered fibroblast cell sheets are a new manageable tool for regenerative medicine to promote wound healing.
  Sci Rep. 12, 12519. 2022
• Yoshimine S, Ueno K, Murakami J, Saito T, Suzuki R, Asai Y, Ikeda E, Tanaka T, Hamano K.
  Autologous multilayered fibroblast sheets can reinforce bronchial stump in a rat model.
  Semin Thorac Cardiovasc Surg. 34, 349-358. 2022
• Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J.
  Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy.
  Circ Res. 129, 1105-1121. 2021 (IF: 16.2)
• Iwamoto K, Saito T *, Takemoto Y, Ueno K, Yanagihara M, Furuya-Kondo T, Kurazumi H, Tanaka Y, Taura Y, Harada E, Hamano K.
  Autologous Transplantation of Multilayered Fibroblast Sheets Prevents Postoperative Pancreatic Fistula by Regulating Fibrosis and Angiogenesis.
  Am J Transl Res. 13, 1257-1268, 2021
• Saito T, Hamano K, Sadoshima J.
  Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart.
  Cardiovasc Res. 117, 2730-2741. 2021 (IF: 13.3)
• Saito T, Kurazumi H, Suzuki R, Matsuno Y, Mikamo A, Hamano K.
  Preserving the Endothelium in Saphenous Vein Graft with Both Conventional and No-touch Preparation.
  J Cardiothoracic Surg. 15, 317, 2020
• Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.
  Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.
  Biochem Biophys Res Commun. 533, 548-552, 2020
• Kaludercic N, Maiuri MC, Kaushik S, Fernández ÁF, de Bruijn J, Castoldi F, Chen Y, Ito J, Mukai R, Murakawa T, Nah J, Pietrocola F, Saito T, Sebti S, Semenzato M, Tsansizi L, Sciarretta S, Madrigal-Matute J.
  Comprehensive autophagy evaluation in cardiac disease models.
  Cardiovasc Res. 116, 483-504, 2020 (IF: 13.3)
• Fujita A, Ueno K, Saito T, Yanagihara M, Kurazumi H, Suzuki R, Mikamo A, Hamano K.
  Hypoxic-conditioned cardiosphere-derived cell sheet transplantation for chronic myocardial infarction.
  Eur J Cardiothorac Surg. 56, 1062-1074, 2019
• Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J.
  Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy.
  Circ Res. 124, 1360-1371, 2019 (IF: 16.2) [CI: 367]
• Venkatesh S, Li M, Saito T, Tong M, Rashed E, Mareedu S, Zhai P, Bárcena C, López-Otín C, Yehia G, Sadoshima J, Suzuki CK.
  Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo.
  J Mol Cell Cardiol. 128: 38-50, 2019
• Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu CP, Kundu M, Sadoshima J.
  An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.
  J Clin Invest. 129, 802-819, 2019 (IF: 13.6) [CI: 204]
• Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Schirone L, Forte M, Rubattu S, Shirakabe A, Boppana VS, Volpe M, Frati G, Zhai P, Sadoshima J.
  Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
  J Am Coll Cardiol. 71, 1999-2010, 2018 (IF: 22.3) [CI: 207]
• Saito T, Sadoshima J.
  Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System.
  Circ Res. 120, 610-612. 2017
• Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J.
  Thioredoxin-1 maintains mTOR function during oxidative stress in cardiomyocytes.
  J Biol Chem. 292, 18988-19000, 2017
• Saito T, Uchiumi T, Yagi M, Amamoto R, Setoyama D, Matsushima Y, Kang D.
  Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses.
  Cardiovasc Res. 113, 1173-1185, 2017 (IF: 13.3)
• Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J.
  Response by Shirakabe et al to Letter Regarding Article, “Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure”.
  Circulation. 134, e75-e76, 2016
• Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J.
  Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure.
  Circulation. 133, 1249-1263, 2016 (IF: 38.6) [CI: 367]
• Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson ÅB, Kitsis RN, Sadoshima J.
  Evaluating mitochondrial autophagy in the mouse heart.
  J Mol Cell Cardiol. 92, 134-139, 2016
• Saito T, Sadoshima J.
  Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart.
  Circ Res. 116, 1477-1490, 2015 (IF: 16.2) [CI: 247]
• Saito T *.
  The vascular clock system generates the intrinsic circadian rhythm of vascular contractility.
  J Smooth Muscle Res. 51, 95-106, 2015
• Saito T, Hirano M, Ide T, Ichiki T, Koibuchi N, Sunagawa K, Hirano K.
  Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.
  Circulation. 127, 104-114, 2013 (IF: 38.6)
• Fang J, Uchiumi T, Yagi M, Matsumoto S, Amamoto R,Saito T, Takazaki S, Kanki T, Yamaza H, Nonaka K, Kang D.
  Protein instability and functional defect by mutations of dihydroorotate dehydrogenase with Miller syndrome patients.
  Biosci Rep. 32, 631-639, 2012
• Matsumoto S, Uchiumi T, Saito T, Yagi M, Takazaki S, Kanki T, Kang D.
  Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins.
  Mitochondrion. 12, 391-398, 2012
• Matsumoto S, Uchiumi T, Tanamachi H, Saito T, Yagi M, Takazaki S, Kanki T, Kang D.
  Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA.
  Biochem J. 443, 573-584, 2012

• Kodama H, Takaki H, Hirata Y, Ueshima E, Kimura Y, Wada R, Osuga K, Yamakado K.
  Unilateral Bleomycin-induced Interstitial Pneumonitis Mouse Model With Both a Healthy and a Diseased Lung. In Vivo. 2025 Jan-Feb;39(1):251-256. doi: 10.21873/invivo.13823. PMID: 39740912; PMCID: PMC11705107.
• Nakai H, Hirata Y, Furue H, Oku Y.
  Electrical stimulation mitigates muscle degradation shift in gene expressions during 12-h mechanical ventilation. Sci Rep. 2023 Nov 17;13(1):20136. doi: 10.1038/s41598-023-47093-w. PMID: 37978221; PMCID: PMC10656540.
• Ueshima E, Sofue K, Takaki H, Hirata Y, Kodama H, Okada T, Yamaguchi M, Yamakado K, Murakami T.
  Lenvatinib Mitigates Transarterial Embolization-Induced Polarization of Tumor-Associated Macrophages in a Rat Hepatocellular Carcinoma Model. J Vasc Interv Radiol. 2023 Nov;34(11):1977-1985.e4. doi: 10.1016/j.jvir.2023.07.025. Epub 2023 Jul 30. PMID: 37527772.
• Maruyama M, Takaki H, Yamada N, Hirata Y, Yamakado K, Kitagak H.
  Liver regeneration after portal vein embolization: Comparison between absolute ethanol and n-butyl-cyanoacrylate in an in vivo rat model. Diagn Interv Radiol 2023 Jan 2. doi: 10.4274/dir.2022.211144.
• Takaki H, Hirata Y, Ueshima E, Kodama H, Matsumoto S, Wada R, Suzuki H, Nakasho K, Yamakado K.
  Hepatic Artery Embolization Enhances Expression of Programmed Cell Death 1 Ligand 1 in an Orthotopic Rat Hepatocellular Carcinoma Model: In vivo and in vitro Experimentation, Journal of Vascular and Interventional Radiology, Sep;31(9):1475-1482
• Ueshima E. Nishiofuku H. · Takaki H. · Hirata Y. · Kodama H. · Tanaka T. · Kichikawa K. · Yamakado K. · Okada T. · Sofue K. · Yamaguchi M. · Sugimoto K. · Murakami T.
  Hepatic Artery Embolization Induces the Local Overexpression of Transforming Growth Factor β1 in a Rat Hepatoma Model. Liver Cancer. 2020 Jan;9(1):63-72
• Hirata Y, Suzuki Y, Oku Y, Tominaga M.
  TRPM8 channel is involved in the ventilatory response to CO2 mediating hypercapnic Ca2+ responses. Respir Physiol Neurobiol. 2019 May; 263:20-25. doi: 10.1016/j.resp.2019.03.002. Epub 2019 Mar 4.

1. Papers

• https://doi.org/10.1038/s41598-023-27893-w
  Y. Oke, F. Miwakeichi, Y. Oku, J. Hirrlinger and S. Hülsmann. Cell types and synchronous-activity patterns of inspiratory neurons in the preBötzinger complex of mouse medullary slices during early postnatal development. Sci. Rep. 13(1): 586 (2023).
• https://doi.org/10.1113/JP276976
  S. Hülsmann, Y. Oke, G. Mesuret, A. T. Latal, M. G. Fortuna, M. Niebert, J. Hirrlinger, J. Fischer and K. Hammerschmidt. The postnatal development of ultrasonic vocalization-associated breathing is altered in glycine transporter 2-deficient mice. J. Physiol. 597(1), 173–191 (2019).
• https://doi.org/10.3389/fphys.2018.01219
  Y. Oke, F. Miwakeichi, Y. Oku, J. Hirrlinger and S. Hülsmann. Cell type-dependent activation sequence during rhythmic bursting in the preBötzinger complex in respiratory rhythmic slices from mice. Front. Physiol. 9, 1219 (2018).
• https://doi.org/10.1016/j.neulet.2015.04.003
  Y. Oke, D. Boiroux, F. Miwakeichi and Y. Oku. Stochastic activation among inspiratory cells in the pre-Bötzinger complex of the rat medulla revealed by Ca²⁺ imaging. Neurosci. Lett. 595, 12–17 (2015).
• https://doi.org/10.1016/j.jneumeth.2014.08.008
  D. Boiroux, Y. Oke, F. Miwakeichi and Y. Oku. Pixel timing correction in Time-lapsed calcium imaging using line scanning microscopy. J. Neurosci. Methods 237, 60–68 (2014).
• https://www.sasappa.co.jp/online/abstract/jsasem/1/048/html/1110480301.html
  Y. Oke, F. Kawano, S. Nomura, T. Ohira, R. Fujita, M. Terada, T. Shibaguchi, N. Nakai and Y. Ohira. Modulation of hippocampal proteins by exposure to simulated microgravity environment during the postnatal development in rats. Jpn. J. Aerospace Environ. Med. 48(3), 23–34 (2011).
• https://doi.org/10.1021/es071805a
  Y. Oke, N. Yamasaki, G. Yamamoto, K. Sasaki, N. Maeta, H. Fujimaki and T. Hashida. Novel selective dyeing method for chrysotile asbestos detection in concrete materials. Environ. Sci. Technol. 42(5), 1638–1642 (2008).
• https://doi.org/10.1016/S0248-4900(03)00009-1
  Y. Oke and A. Inoue. The interaction of two classes of nuclear vesicles is induced by the dissociation of soluble proteins from one class of vesicles. Biol. Cell 95(2), 87–97 (2003).

I.Original articles (* indicates a corresponding author)

• Fujiwara Y, Koga K*, Nakamura NH, Maruo K, Tachibana T*, Furue H. (2024) Optogenetic inhibition of spinal inhibitory neurons facilitates mechanical responses of spinal wide dynamic range neurons and causes mechanical hypersensitivity. Neuropharmachology. 242:109763.
• Nakamura NH*, Furue H, Kobayashi K, Oku Y. (2023) Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding. Nature Communications. 14:4391.
• Nakamura NH*, Fukunaga M, Yamamoto T, Sadato N, Oku Y. (2022) Respiration- timing-dependent changes in activation of neural substrates during cognitive processes. Cerebral Cortex Communications. 3:tgac038.
• Nakamura NH*, Fukunaga M, Oku Y (2019) Respiratory fluctuations in pupil diameter are not maintained during cognitive tasks. Respiratory Physiology and Neurobiology. 265:68-75.
• Nakamura NH*, Fukunaga M, Oku Y (2018) Respiratory modulation of cognitive performance during the retrieval process. PLoS ONE. 13:e0204021.
• Flasbeck V, Atucha E, Nakamura NH, Yoshida M, Sauvage MM* (2018) Spatial information is preferentially processed by the distal part of CA3: implication for memory retrieval. Behavioural Brain Research. 347:116-123.
• Ku SP¶, Nakamura NH¶, Maingret N, Mahnke L, Yoshida M, Sauvage MM* (2017) Regional specific evidence for memory-load dependent activity in the dorsal subiculum and the lateral entorhinal cortex. Frontiers in System Neuroscience. 11:51. ※¶ indicates equal contribution
• Nakamura NH, Sauvage MM* (2016) Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus. Hippocampus. 26:67-75.
• Nakamura NH, Flasbeck V, Maingret N, Kitsukawa T, Sauvage MM* (2013) Proximodistal segregation of nonspatial information in CA3: Preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory. Journal of Neuroscience. 33:11506-11514.
• Nakamura NH*, Akiyama K, Naito T (2011b) Suppression of cAMP-dependent gene expression by cholecystokinin in the hippocampus. Neuroscience. 187:15-23.
• Nakamura NH*, Akiyama K. Naito T (2011a) Quantitative gene expression analysis of the ligand-receptor system for classical neurotransmitters and neuropeptides in hippocampal CA1 and CA3 and dentate gyrus. Hippocampus. 21:1228-1239.
• Nakamura NH*, Fukunaga M, Akama KT, Soga T, Ogawa S, Pavlides C (2010) Hippocampal cells encode places by small anatomical clusters. Neuroscience. 166:994-10 ※Selected Faculty of 1000 Biology
• Akiyama K*, Nakanishi S, Nakamura NH, Naito T (2008) Gene expression profiling of neuropeptides in mouse cerebellum, hippocampus, and retina. Nutrition. 24:918-923.
• Nakamura NH*, McEwen BS (2005) Changes in interneuronal phenotypes regulated by estradiol in the adult rat hippocampus: A potential role for Neuropeptide Y. Neuroscience. 136:357-369.
• Nakamura NH*, Rossell DR, Akama KT, McEwen BS (2004) Estrogen and ovariectomy regulate mRNA and protein of glutamic acid decarboxylase and cation-chloride cotransporters in the adult rat hippocampus. Neuroendocrinology. 80:308-323.
• Nakamura N, Fujita H, Kawata M* (2002) Effects of gonadectomy on immunoreactivity for choline acetyltransferase in the cortex, hippocampus, and basal forebrain of adult male rats. Neuroscience. 109:473-485.
• Nakamura N, Yamamoto T, Saito T*, Fujita H (2000) Analysis of activation in anterior cingulate cortex during cognitive process of selection following somatosensory stimuli: fMRI study with elaborate task paradigms. Magnetic Resonance Imaging. 18:397-404.

II. Review articles (* indicates a corresponding author)

• Nakamura NH* (2025) Perspective of brain functions via respiration – A potential role of temporal coding (Japanese). Igaku no Ayumi. In press.
• Nakamura NH*, Fukunaga M, Oku Y. (2024) “Brain-breath” interactions: Respiration- timing-dependent impact on functional brain networks and beyond. Reviews in the Neurosciences. 35:165-182.
• Nakamura NH* (2024) Neural networks of interoception regulating brain functions (Japanese). Hyogo Medical University Igaku Kai Zasshi 48:27-33.
• Nakamura NH* (2016) Respiration for living better in stress society (Japanese). Environment and Health 29:185-193.
• Sauvage MM*, Nakamura NH, Beer Z (2013) Mapping memory function in the medial temporal lobe with the immediate-early gene Arc. Behavioural Brain Research. 254:22-33.
• Nakamura NH*, Akama KT, Yuen GS, McEwen BS (2007) Thinking outside the pyramidal cell: Unexplored contributions of interneurons and neuropeptide Y to estrogen- induced synapse formation in the hippocampus. Reviews in the Neurosciences. 18:1-13.
• Kawata M* Ochiai I, Nakamura NH (2000) Functions of androgen for the brain (Japanese). Seisa Igaku 6:13-23.

III. Books

• Nakamura NH* (2024)　4. Assessment of improved task-related concentration via respiratory pressure monitoring and functional MRI (Japanese). Development of Biosensing technologies and their applications in thcare and remote diagnosis. Gijyutu Joho Kyokai Press, Japan. pp.412-421.
• Saito T*, Nakagawa N, Takahashi K, Li D, Yamamoto Y, Sasaki H, Nakamura N, Ogawa K, Fujita H, Kurasaki M, Okabe M, Hosokawa T (2000) Zinc-induced excessive glutamate release may cause accelerated senescence with defect in learning and memory in senescence accelerated mouse. Trace Elements in Man and Animals 10, Kluwer Academic/ Plenum Publishers, New York, pp.429-432.

IV. Others

• Nakamura NH* (2023) Breathing to restore myself (Japanese). Hanshin Hankyu Health information Zasshi Well TOKK autumn vol. 31: 2-3.
• Nakamura NH* (2019) Reading the opponent’s breath – Scientific insights Applied to martial arts (Japanese). Hiden BAB Japan. March: 50-54.
• Nakamura NH* (2002) Study abroad in Rockefeller University, USA (Japanese). Hokkaido Igaku Zasshi 77:581-583.
• >Yamamoto T, Kumazawa S, Nakamura N, Miyasaka K (1999) A quantitative analysis of artifacts in fMRI. Proceedings of the International Society for Magnetic Resonance in Medicine Seventh Scientific Meeting, 3, 1676.
• Kumazawa S, Yamamoto T, Nakamura N, Yamamoto T, Miyasaka K (1999) Evaluation of motion correction in fMRI – Dependency of spatial resolution -. Proceedings of the International Society for Magnetic Resonance in Medicine Seventh Scientific Meeting, 3, 1675.
• Nakamura NH*, Yoshino K, Fukunaga. Breath as phase-dependent context: respiratory alignment between encoding and retrieval shapes cognitive load. submitted.
• Nakamura NH*, Yoshino K, Fukunaga. Task-related vigilance is distinctly modulated by respiration and cardiac pulse tone. submitted.