Despite great advances in medical science, numerous patients still suffer from high rates of morbidity and disability. Pathologies often consist of a broad array of complicated mechanisms that intertwine and create vicious cycles. For instance, heart failure, a final common state of cardiovascular disease, manifests as multiple disorders (e.g. mitochondrial abnormality, metabolic dysregulation, loss of contractility) exacerbating one another. Accordingly, it can be difficult to identify the appropriate molecular targets for therapeutic intervention. While patients can partially recover from some disorders, this salutary effect may be overwhelmed by residual malignant cycles, leading to incomplete restoration of their state.
A thorough understanding of the mechanisms underlying homeostasis is essential for unraveling the tangled threads of pathology and can facilitate the development of novel therapies that efficiently contribute to patient welfare.
Since metabolic disorders are a leading cause of death in developed and aging societies, we are conducting intensive study in this field. We are also investigating neurohormonal regulation and cancer.